Hmmm. You can certainly hike cross-country from about the 10,000 foot level due South of Conness and just contour around past Roosevelt Lake and then to Lower McCabe Lake..and McCabe Creek. Is that what you mean? There is no trail there, but except for some crummy talus on Conness, that's a relatively straightforward route-finding exercise. Nice hike, too.
So your route could be from TM to Young Lakes, then day two climb Conness and head over to Roosevelt Lake. Day Three gets you to McCabe Lakes--maybe Upper McCabe, since you'll have plenty of time, and then days four and five on the Pacific Crest Trail to Glen Aulin and back to Tuolumne Meadows.
But if you want to stay on a trail, that's not an option.
Do you have a permit already? For which trailhead?
If you want a loop hike, there are more options going SOUTH from Tuolumne Meadows, mostly heading over to Merced Lake and then back again, via Rafferty Creek, Lyell Canyon, Cathedral Lakes...Go in via one trail and back out via another trail, and you've got your loop.
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