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The Other Tom
A friend is planning to fly to Vegas and wants to go to Yosemite and was wondering what route to take and what to see along the way. Their trip will be the first week of Oct. I've looked at the map and some possibilities are Hoover dam, Death Valley, Sequoia ? and of course Yosemite. Tioga road may or may not be open then, but in any event everything in TM will be closed. My guess is the best way to go is to make their way to Fresno and then head to Yosemite, but I'm looking for suggestions. Oh, they have one week to do the trip.
First, it's 99% certain that Tioga Pass
WILL BE OPEN during the first week of October.
Since the Park Service modernized and paved Tioga Road over 50 years ago (in 1961), the earliest that Tioga Pass has been closed for the season was Oct. 17 which happened only ONCE in 2004. The next earliest closing was on Oct. 24 and that happened only ONCE in 1996.
Yes, there is still maybe a 1% chance that Tioga Road will be TEMPORARILY closed for a day or so if an early Sierra storm passes through in early October, but that would still be a very, very rare occurrence.
In other words, it safe to assume that Tioga Road will be open for your friend's trip.
Also note that Tuolumne Meadows will NOT BE CLOSED in October. It's always open 365 days a year.

Yes, all the guest services will probably be closed including the service station (so fill up in Lee Vining) but Tuolumne Meadows itself will be as beautiful as ever but with far less crowds and almost no (if any) mosquitos! October is a great time to visit and explore Tuolumne Meadows and its environs.
About what to visit between Las Vegas and Yosemite, I recommend the general route recommended by Half Dome Hiker (Las Vegas - Pahrump - Death Valley - Lone Pine - Bishop - Lee Vining - Yosemite).
Note though that Death Valley will most likely still be scorching hot in early October so I would NOT recommend hiking out to the sand dunes unless the temps are in the low 90's or lower. But if your friend still wants to, be sure to bring plenty of water on the hike to the dunes. What's more pleasant to do in Death Valley National Park when the Death Valley itself is so hot is to explore its highlands like Wildrose Canyon and the nearby charcoal kilns, a fascinating place for a day hike.
Along US-395, I would also recommend making a detour by taking State Hwy 168 East to the White Mountains to visit the ancient Bristlecone Pine groves (at least the Schulman Grove and its brand spanking new Vistor Center).
Besides the Alabama Hills, there's great day hiking opportunities along US-395 in the Eastern Sierra including the trailheads at Sabrina Lake, North Lake and South Lake on CA-168 West or at the end of Rock Creek Road among many other trailheads. If you friend enjoys photography, I would also recommend your friend stopping by at the Mountain Light Gallery in Bishop which hosts the extensive collection of photographs of noted nature photographer Galen Rowell and his wife Barbara.
Besides the Creekside Inn in Bishop, I would also recommend the Holiday Inn Express across the street from the Creekside Inn. In Lee Vining, I've always had a good stay at Murphey's Motel.
But what is your friend planning to do about accommodation while visiting Yosemite itself? Do they already have room reservations, are they planning to camp in a campground? Especially for first time visitors, I always recommend staying inside Yosemite Valley itself. It's a drag to have to go back and forth from lodging accommodations located outside of Yosemite Valley even if they do cost a lot less.
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